Isopropyl myristate

Isopropyl myristate[1]
Names
IUPAC name
Propan-2-yl tetradecanoate
Other names
Tetradecanoic acid, 1-methylethyl ester
Myristic acid isopropyl ester
Identifiers
110-27-0 YesY
3D model (Jmol) Interactive image
ChemSpider 7751 N
ECHA InfoCard 100.003.412
EC Number 203-751-4
KEGG D02296 N
MeSH C008205
PubChem 8042
RTECS number XB8600000
Properties
C17H34O2
Molar mass 270.46 g·mol−1
Density 0.85 g/cm³
Boiling point 167 °C (333 °F; 440 K) at 9 mmHg
Hazards
R-phrases R38
S-phrases S24/25
NFPA 704
Flammability code 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g., canola oil Health code 0: Exposure under fire conditions would offer no hazard beyond that of ordinary combustible material. E.g., sodium chloride Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
1
0
0
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Isopropyl myristate is the ester of isopropanol and myristic acid.

Uses

Isopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption the skin is desired. Isopropyl myristate is being study as a skin enhancer. It is also used as a pesticide-free treatment against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.[2]

It is used as a solvent in perfume materials.

It is the non-aqueous component of the two-phase mouthwash, Dentyl pH, where it removes bacteria from the oral cavity.

It is also used in the removal process of prosthetic make-up.

It is also used in flea and tick products for pets.

The hydrolysis of the ester from isopropyl myristate can liberate the acid and the alcohol. The acid could be responsible for decreasing of the pH value of formulations.[3] [4]

References

  1. ↑ MSDS for isopropyl myristate
  2. ↑ Anti-Lice Treatments
  3. ↑ Wen, Z.; Fang, L. and He, Z. (2009). Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myristate vehicle across rat skin in vitro. Drug Deliv, 16: 214-223
  4. ↑ Engelbrecht, T.; Demé, B.; Dobner, B. and Neubert, R. (2012). Study of the influence of the penetration enhancer isopropyl myristate on the nanostructure of stratum corneum lipid model membranes using neutron diffraction and deuterium labelling. Skin Pharmacol Physiol, 25:200-7
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