Insulysin

Identifiers

Databases

PDB structures

Insulysin (EC 3.4.24.56, insulinase, insulin-degrading enzyme, insulin protease, insulin proteinase, insulin-degrading neutral proteinase, insulin-specific protease, insulin-glucagon protease, metalloinsulinase, IDE) is an enzyme.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

Degradation of insulin, glucagon and other polypeptides. No action on proteins

This cytosolic enzyme is present in mammals and in many arthropods such as the fly Drosophila melanogaster.

References

↑ Duckworth, W.C. (1988). "Insulin degradation: mechanisms, products, and significance". Endocrine Rev. 9: 319–345. doi:10.1210/edrv-9-3-319. PMID 3061785.
↑ Affholter, J.A.; Hsieh, C.-L.; Francke, U.; Roth, R.A. (1990). "Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes". Mol. Endocrinol. 4: 1125–1135. doi:10.1210/mend-4-8-1125. PMID 2293021.
↑ Duckworth, W.C.; Hamel, F.G.; Bennett, R.; Ryan, M.P.; Roth, R.A. (1990). "Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin". J. Biol. Chem. 265: 2984–2987. PMID 1689296.
↑ Kuo, W.-L.; Gehm, B.D.; Rosner, M.R. (1990). "Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme". Mol. Endocrinol. 4: 1580–1591. doi:10.1210/mend-4-10-1580. PMID 2126597.
↑ Ding, L.; Becker, A.B.; Suzuki, A.; Roth, R.A. (1992). "Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III". J. Biol. Chem. 267: 2414–2420. PMID 1733942.

Insulysin at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: metalloendopeptidases (EC 3.4.24)

ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13

Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28

Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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