IPO8

IPO8
Identifiers
Aliases IPO8, RANBP8, importin 8
External IDs MGI: 2444611 HomoloGene: 48430 GeneCards: IPO8
Orthologs
Species Human Mouse
Entrez

10526

320727

Ensembl

ENSG00000133704

ENSMUSG00000040029

UniProt

O15397

Q7TMY7

RefSeq (mRNA)

NM_001190995
NM_006390

NM_001081113

RefSeq (protein)

NP_001177924.1
NP_006381.2

NP_001074582.1

Location (UCSC) Chr 12: 30.63 – 30.7 Mb Chr 6: 148.77 – 148.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Importin 8 is a protein that in humans is encoded by the IPO8 gene.[3]

Function

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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