IGHE

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
1F6A, 1FP5, 1G84, 1O0V, 2WQR, 2Y7Q, 3H9Y, 3H9Z, 3HA0, 4EZM, 4GKO, 4GRG, 4GT7, 4J4P, 4KI1, 5ANM, 5HYS

Identifiers

Aliases

IGHE, IgE, immunoglobulin heavy constant epsilon

External IDs

GeneCards: IGHE

Gene ontology
Molecular function	• immunoglobulin receptor binding • antigen binding
Cellular component	• extracellular region • blood microparticle • external side of plasma membrane • immunoglobulin complex, circulating
Biological process	• B cell receptor signaling pathway • phagocytosis, recognition • Fc-epsilon receptor signaling pathway • positive regulation of B cell activation • phagocytosis, engulfment • defense response to bacterium • immune response • complement activation, classical pathway • innate immune response
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3497


n/a

Ensembl


n/a


n/a

UniProt


P01854


n/a

RefSeq (mRNA)


n/a


n/a

RefSeq (protein)


n/a


n/a

Location (UCSC)

n/a

PubMed search

^[1]

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Wikidata

View/Edit Human

Ig epsilon chain C region is a protein that in humans is encoded by the IGHE gene.^[2]

References

Venkitaraman AR, Williams GT, Dariavach P, Neuberger MS (Aug 1991). "The B-cell antigen receptor of the five immunoglobulin classes". Nature. 352 (6338): 777–81. doi:10.1038/352777a0. PMID 1881434.
Padlan EA, Davies DR (Oct 1986). "A model of the Fc of immunoglobulin E". Molecular Immunology. 23 (10): 1063–75. doi:10.1016/0161-5890(86)90005-2. PMID 3796618.
Flanagan JG, Rabbitts TH (1984). "The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes". The EMBO Journal. 1 (5): 655–60. PMC 553102. PMID 6234164.
Max EE, Battey J, Ney R, Kirsch IR, Leder P (Jun 1982). "Duplication and deletion in the human immunoglobulin epsilon genes". Cell. 29 (2): 691–9. doi:10.1016/0092-8674(82)90185-4. PMID 6288268.
Ellison J, Buxbaum J, Hood L (1983). "Nucleotide sequence of a human immunoglobulin C gamma 4 gene". Dna. 1 (1): 11–8. doi:10.1089/dna.1.1981.1.11. PMID 6299662.
Seno M, Kurokawa T, Ono Y, Onda H, Sasada R, Igarashi K, Kikuchi M, Sugino Y, Nishida Y, Honjo T (Feb 1983). "Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA". Nucleic Acids Research. 11 (3): 719–26. doi:10.1093/nar/11.3.719. PMC 325748. PMID 6300763.
Ueda S, Nakai S, Nishida Y, Hisajima H, Honjo T (1984). "Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns". The EMBO Journal. 1 (12): 1539–44. PMC 553248. PMID 6327276.
Hisajima H, Nishida Y, Nakai S, Takahashi N, Ueda S, Honjo T (May 1983). "Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin". Proceedings of the National Academy of Sciences of the United States of America. 80 (10): 2995–9. doi:10.1073/pnas.80.10.2995. PMC 393960. PMID 6407005.
Flanagan JG, Lefranc MP, Rabbitts TH (Mar 1984). "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences". Cell. 36 (3): 681–8. doi:10.1016/0092-8674(84)90348-9. PMID 6421489.
Ellison J, Hood L (Mar 1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes". Proceedings of the National Academy of Sciences of the United States of America. 79 (6): 1984–8. doi:10.1073/pnas.79.6.1984. PMC 346106. PMID 6804948.
Kenten JH, Molgaard HV, Houghton M, Derbyshire RB, Viney J, Bell LO, Gould HJ (Nov 1982). "Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line". Proceedings of the National Academy of Sciences of the United States of America. 79 (21): 6661–5. doi:10.1073/pnas.79.21.6661. PMC 347188. PMID 6815656.
Valenta R, Natter S, Seiberler S, Wichlas S, Maurer D, Hess M, Pavelka M, Grote M, Ferreira F, Szepfalusi Z, Valent P, Stingl G (Dec 1998). "Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients". The Journal of Investigative Dermatology. 111 (6): 1178–83. doi:10.1046/j.1523-1747.1998.00413.x. PMID 9856836.
Anderson GG, Leaves NI, Bhattacharyya S, Zhang Y, Walshe V, Broxholme J, Abecasis G, Levy E, Zimmer M, Cox R, Cookson WO (Apr 2002). "Positive association to IgE levels and a physical map of the 13q14 atopy locus". European Journal of Human Genetics. 10 (4): 266–70. doi:10.1038/sj.ejhg.5200801. PMID 12032735.
Cocco RR, Järvinen KM, Sampson HA, Beyer K (Aug 2003). "Mutational analysis of major, sequential IgE-binding epitopes in alpha s1-casein, a major cow's milk allergen". The Journal of Allergy and Clinical Immunology. 112 (2): 433–7. doi:10.1067/mai.2003.1617. PMID 12897753.
Hajoui O, Janani R, Tulic M, Joubert P, Ronis T, Hamid Q, Zheng H, Mazer BD (Sep 2004). "Synthesis of IL-13 by human B lymphocytes: regulation and role in IgE production". The Journal of Allergy and Clinical Immunology. 114 (3): 657–63. doi:10.1016/j.jaci.2004.05.034. PMID 15356573.
Takhar P, Smurthwaite L, Coker HA, Fear DJ, Banfield GK, Carr VA, Durham SR, Gould HJ (Apr 2005). "Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis". Journal of Immunology. 174 (8): 5024–32. doi:10.4049/jimmunol.174.8.5024. PMID 15814733.
Batra J, Rajpoot R, Ahluwalia J, Devarapu SK, Sharma SK, Dinda AK, Ghosh B (Jun 2007). "A hexanucleotide repeat upstream of eotaxin gene promoter is associated with asthma, serum total IgE and plasma eotaxin levels". Journal of Medical Genetics. 44 (6): 397–403. doi:10.1136/jmg.2006.046607. PMC 2740889. PMID 17220216.

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IGHE

References

Further reading