Hyalobarrier
Hyalobarrier is a substance to keep tissue apart post surgery and therefore prevent adhesions. It contains autocross-linked hyaluronan. Highly viscous due to condensation. Hyaluronan is present in cartilage and skin hence there is a natural metabolic pathway for it. This gel is used to separate organs and tissue after surgery. Scientific documentation so far covers the gynaecology speciality. IE Laparoscopic surgery, hysteroscopy/hysteroscopic surgery but also open surgery. According to data in a Cochrane collaboration review active action to prevent adhesions needs to be taken to a larger extent. The Cochrane report also states that the incidence of postsurgical adhesions is as high as 60 to 90%.[1] In a recent review by C Sutton (University of Surrey, Guilford UK), it is stated that Hyalobarrier is the only anti adhesive substance that has published data for intrauterine use.[2]
Additional information
References
- Mais V, Bracco GL, Litta P, Gargiulo T, Melis GB (May 2006). "Reduction of postoperative adhesions with an auto-crosslinked hyaluronan gel in gynaecological laparoscopic surgery: a blinded, controlled, randomized, multicentre study". Hum. Reprod. 21 (5): 1248–54. doi:10.1093/humrep/dei488. PMID 16439505.
- ↑ Ahmad G, Duffy JM, Farquhar C, et al. (2008). "Barrier agents for adhesion prevention after gynaecological surgery". Cochrane Database Syst Rev (2): CD000475. doi:10.1002/14651858.CD000475.pub2. PMID 18425865.
- ↑ Sutton C (2009). "Adhesions following surgery: pathogenesis and current experience with adhesion barriers". Surg Technol Int. 18: 144–56. PMID 19579202.