DEFA4

DEFA4
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
Aliases DEFA4, DEF4, HNP-4, HP-4, HP4, defensin alpha 4
External IDs HomoloGene: 48059 GeneCards: DEFA4
Orthologs
Species Human Mouse
Entrez

1669

n/a

Ensembl

ENSG00000164821

n/a

UniProt

P12838

n/a

RefSeq (mRNA)

NM_001925

n/a

RefSeq (protein)

NP_001916.1

n/a

Location (UCSC) Chr 8: 6.94 – 6.94 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Defensin, alpha 4 (DEFA4), also known as neutrophil defensin 4 or HNP4, is a human defensin peptide that is encoded by the DEFA4 gene.[2][3] HNP4 is expressed in the granules of the neutrophil where it defends the host against bacteria[4] and viruses.[5]

Function

Defensins are a peptide family of cytotoxic microbicides involved in innate immunity.[6] Members of the defensin family are distinguished by a conserved six-cysteine motif. Several human alpha defensin genes including HNP4 are clustered on chromosome 8. DEFA4 differs from other defensin genes by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. HNP4 inhibits corticotropin-stimulated corticosterone production.[2]

References

  1. "Human PubMed Reference:".
  2. 1 2 "Entrez Gene: DEFA4; defensin, alpha 4, corticostatin (Homo sapiens)".
  3. Wu Z, Ericksen B, Tucker K, et al. (2004). "Synthesis and characterization of human alpha-defensins 4-6.". J Pept Res. 64 (3): 118–25. doi:10.1111/j.1399-3011.2004.00179.x. PMID 15317502.
  4. Ericksen B, Wu Z, Lu W, Lehrer RI (2005). "Antibacterial Activity and Specificity of the Six Human α-Defensins". Antimicrob Agents Chemother. 49 (1): 269–75. doi:10.1128/AAC.49.1.269-275.2005. PMC 538877Freely accessible. PMID 15616305.
  5. Wu Z, Cocchi F, Gentles D, et al. (3 January 2005). "Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro". FEBS Lett. 579 (1): 162–6. doi:10.1016/j.febslet.2004.11.062. PMID 15620707.
  6. T Ganz; M E Selsted; D Szklarek; et al. (1985). "Defensins. Natural peptide antibiotics of human neutrophils". J Clin Invest. 76 (4): 1427–1435. doi:10.1172/JCI112120. PMC 424093Freely accessible. PMID 2997278.

Further reading


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