HIP1R

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1R0D

Identifiers

Aliases

HIP1R, HIP12, HIP3, ILWEQ, huntingtin interacting protein 1 related

External IDs

MGI: 1352504 HomoloGene: 78348 GeneCards: HIP1R

Gene ontology
Molecular function	• clathrin binding • actin binding • protein binding • phospholipid binding • phosphatidylinositol binding
Cellular component	• perinuclear region of cytoplasm • clathrin-coated pit • cytoskeleton • clathrin-coated vesicle membrane • intracellular membrane-bounded organelle • endomembrane system • membrane • cytoplasmic vesicle • clathrin-coated vesicle • cytoplasm
Biological process	• clathrin-dependent endocytosis • endocytosis • receptor-mediated endocytosis • apoptotic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


9026


29816

Ensembl


ENSG00000130787


ENSMUSG00000000915

UniProt


O75146


Q9JKY5

RefSeq (mRNA)


NM_001303097 NM_001303099 NM_003959


NM_145070

RefSeq (protein)


NP_001290026.1 NP_003950.1


NP_659507.3

Location (UCSC)

Chr 12: 122.83 – 122.86 Mb

Chr 5: 123.97 – 124.01 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Huntingtin-interacting protein 1-related protein is a protein that in humans is encoded by the HIP1R gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Brett TJ, Legendre-Guillemin V, McPherson PS, Fremont DH (Feb 2006). "Structural definition of the F-actin-binding THATCH domain from HIP1R". Nat Struct Mol Biol. 13 (2): 121–30. doi:10.1038/nsmb1043. PMID 16415883.
↑ "Entrez Gene: HIP1R huntingtin interacting protein 1 related".

Parker JA, Metzler M, Georgiou J, et al. (2007). "Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.". J. Neurosci. 27 (41): 11056–64. doi:10.1523/JNEUROSCI.1941-07.2007. PMID 17928447.
Bradley SV, Hyun TS, Oravecz-Wilson KI, et al. (2007). "Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1.". Hum. Mol. Genet. 16 (11): 1279–92. doi:10.1093/hmg/ddm076. PMID 17452370.
Provençal N, Shink E, Harvey M, et al. (2005). "Analysis of a variable number tandem repeat polymorphism in the huntingtin interacting protein-1 related gene for anticipation in bipolar affective disorder.". Prog. Neuropsychopharmacol. Biol. Psychiatry. 28 (8): 1299–303. doi:10.1016/j.pnpbp.2004.07.001. PMID 15588756.
Senetar MA, Foster SJ, McCann RO (2005). "Intrasteric inhibition mediates the interaction of the I/LWEQ module proteins Talin1, Talin2, Hip1, and Hip12 with actin.". Biochemistry. 43 (49): 15418–28. doi:10.1021/bi0487239. PMID 15581353.
Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8.". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703.
Engqvist-Goldstein AE, Zhang CX, Carreno S, et al. (2004). "RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery.". Mol. Biol. Cell. 15 (4): 1666–79. doi:10.1091/mbc.E03-09-0639. PMC 379265. PMID 14742709.
Hyun TS, Rao DS, Saint-Dic D, et al. (2004). "HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains.". J. Biol. Chem. 279 (14): 14294–306. doi:10.1074/jbc.M312645200. PMID 14732715.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Legendre-Guillemin V, Metzler M, Charbonneau M, et al. (2002). "HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.". J. Biol. Chem. 277 (22): 19897–904. doi:10.1074/jbc.M112310200. PMID 11889126.
Chopra VS, Metzler M, Rasper DM, et al. (2001). "HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.". Mamm. Genome. 11 (11): 1006–15. doi:10.1007/s003350010195. PMID 11063258.
Seki N, Muramatsu M, Sugano S, et al. (1999). "Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1).". J. Hum. Genet. 43 (4): 268–71. doi:10.1007/s100380050087. PMID 9852681.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
Puigvert A (1976). "Caliceal urodynamics.". Urol. Int. 30 (4): 282–96. doi:10.1159/000279990. PMID 1189126.

PDB gallery

1r0d: HIP1R THATCH DOMAIN CORE

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HIP1R

References

Further reading