HAGH

HAGH

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1QH3, 1QH5

Identifiers

HAGH, GLO2, GLX2, GLXII, HAGH1, hydroxyacylglutathione hydrolase

External IDs

MGI: 95745 HomoloGene: 3890 GeneCards: HAGH

Gene ontology
Molecular function	• hydroxyacylglutathione hydrolase activity • protein binding • hydrolase activity • metal ion binding
Cellular component	• cytoplasm • cytosol • mitochondrial matrix • extracellular exosome • mitochondrion
Biological process	• methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione • glutathione biosynthetic process • pyruvate metabolic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


3029


14651


ENSG00000063854


ENSMUSG00000024158


Q16775


Q99KB8

RefSeq (mRNA)


NM_001040427 NM_001286249 NM_005326


NM_001159626 NM_024284

RefSeq (protein)


NP_001035517.1 NP_001273178.1 NP_005317.2


NP_001153098.1 NP_077246.2

Location (UCSC)

Chr 16: 1.8 – 1.83 Mb

Chr 17: 24.84 – 24.86 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Hydroxyacylglutathione hydrolase, mitochondrial is an enzyme that in humans is encoded by the HAGH gene.^[3]^[4]^[5]

The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate.^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Mulley JC, Callen DF (Feb 1987). "New regional localisations for HAGH and PGP on human chromosome 16". Hum Genet. 74 (4): 423–4. doi:10.1007/BF00280498. PMID 3025077.
↑ Honey NK, Shows TB (Apr 1982). "Assignment of the glyoxalase II gene (HAGH) to human chromosome 16". Hum Genet. 58 (4): 358–61. doi:10.1007/bf00282815. PMID 7327557.
1 2 "Entrez Gene: HAGH hydroxyacylglutathione hydrolase".

Further reading

Kar NC, Pearson CM (1976). "Glyoxalase enzyme system in human muscular dystrophy". Clin. Chim. Acta. 65 (1): 153–5. doi:10.1016/0009-8981(75)90348-4. PMID 1192606.
Hamilton DS, Creighton DJ (1993). "Inhibition of glyoxalase I by the enediol mimic S-(N-hydroxy-N-methylcarbamoyl)glutathione. The possible basis of a tumor-selective anticancer strategy". J. Biol. Chem. 267 (35): 24933–6. PMID 1459997.
Mulley JC, Barton N, Callen DF (1990). "Localisation of human PGP and HAGH genes to 16p13.3". Cytogenet. Cell Genet. 53 (2–3): 175–6. doi:10.1159/000132923. PMID 2164460.
Talesa V, Uotila L, Koivusalo M, et al. (1988). "Demonstration of glyoxalase II in rat liver mitochondria. Partial purification and occurrence in multiple forms". Biochim. Biophys. Acta. 955 (1): 103–10. doi:10.1016/0167-4838(88)90183-5. PMID 3382669.
Thornalley PJ, Bellavite P (1987). "Modification of the glyoxalase system during the functional activation of human neutrophils". Biochim. Biophys. Acta. 931 (2): 120–9. doi:10.1016/0167-4889(87)90198-4. PMID 3663711.
Valentine WN, Paglia DE, Neerhout RC, Konrad PN (1971). "Erythrocyte glyoxalase II deficiency with coincidental hereditary elliptocytosis". Blood. 36 (6): 797–808. PMID 5485124.
Leoncini G, Maresca M, Balestrero F, et al. (1984). "Platelet glyoxalases in thrombocytosis". Scandinavian journal of haematology. 33 (1): 91–4. doi:10.1111/j.1600-0609.1984.tb02216.x. PMID 6463589.
Board PG (1980). "Genetic polymorphism of human erythrocyte glyoxalase II". Am. J. Hum. Genet. 32 (5): 690–4. PMC 1686103. PMID 7424909.
Di Ilio C, Angelucci S, Pennelli A, et al. (1995). "Glyoxalase activities in tumor and non-tumor human urogenital tissues". Cancer Lett. 96 (2): 189–93. doi:10.1016/0304-3835(95)03928-P. PMID 7585456.
Ridderström M, Saccucci F, Hellman U, et al. (1996). "Molecular cloning, heterologous expression, and characterization of human glyoxalase II". J. Biol. Chem. 271 (1): 319–23. doi:10.1074/jbc.271.1.319. PMID 8550579.
Cameron AD, Ridderström M, Olin B, Mannervik B (1999). "Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue". Structure. 7 (9): 1067–78. doi:10.1016/S0969-2126(99)80174-9. PMID 10508780.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Rulli A, Carli L, Romani R, et al. (2001). "Expression of glyoxalase I and II in normal and breast cancer tissues". Breast Cancer Res. Treat. 66 (1): 67–72. doi:10.1023/A:1010632919129. PMID 11368412.
Scirè A, Saccucci F, Bertoli E, et al. (2002). "Effect of acidic phospholipids on the structural properties of recombinant cytosolic human glyoxalase II". Proteins. 48 (1): 126–33. doi:10.1002/prot.10149. PMID 12012344.
Mearini E, Romani R, Mearini L, et al. (2002). "Differing expression of enzymes of the glyoxalase system in superficial and invasive bladder carcinomas". Eur. J. Cancer. 38 (14): 1946–50. doi:10.1016/S0959-8049(02)00236-8. PMID 12204678.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cordell PA, Futers TS, Grant PJ, Pease RJ (2004). "The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II". J. Biol. Chem. 279 (27): 28653–61. doi:10.1074/jbc.M403470200. PMID 15117945.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

PDB gallery

1qh3: HUMAN GLYOXALASE II WITH CACODYLATE AND ACETATE IONS PRESENT IN THE ACTIVE SITE

1qh5: HUMAN GLYOXALASE II WITH S-(N-HYDROXY-N-BROMOPHENYLCARBAMOYL)GLUTATHIONE

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