Glycolipid transfer protein
| Glycolipid transfer protein (GLTP) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||||
| Symbol | GLTP | ||||||||
| Pfam | PF08718 | ||||||||
| InterPro | IPR014830 | ||||||||
| OPM superfamily | 92 | ||||||||
| OPM protein | 1swx | ||||||||
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Glycolipid transfer protein is a cytosolic protein that catalyses the transfer of glycolipids between different intracellular membranes.[1][2]
It was discovered by Raymond J. Metz and Norman S. Radin in 1980 and partially purified and characterized in 1982.[3][4]
Recent reviews on structure and possible function are available.[5][6]
This protein transport primarily different glycosphingolipids and glyceroglycolipids between intracellular membranes, but not phospholipids. It might be also involved in translocation of glucosylceramides. It was found in brain, kidney, spleen, lung, cerebellum, liver and heart.
Human proteins containing this domain
GLTP; PLEKHA8; PLEKHA9;
References
- ↑ Brown RE, Lin X, Rao CS, Pike HM, Molotkovsky JG (2004). "Glycolipid Transfer Protein Mediated Transfer of Glycosphingolipids between Membranes: A Model for Action Based on Kinetic and Thermodynamic Analyses". Biochemistry. 43 (43): 13805–15. doi:10.1021/bi0492197. PMC 2596630
. PMID 15504043. - ↑ Nymalm Y, Airenne TT, Kidron H, Salminen TA, Nylund M, West G, Mattjus P (2006). "Structural evidence for adaptive ligand binding of glycolipid transfer protein". J. Mol. Biol. 355 (2): 224–36. doi:10.1016/j.jmb.2005.10.031. PMID 16309699.
- ↑ Metz, RJ, and Radin, NS. Glucosylceramide Uptake Protein from Spleen Cytosol. Journal of Biological Chemistry. 1980;255(10):4463–67. PMID 7372587.
- ↑ Metz, RJ, and Radin NS. Purification and Properties of a Cerebroside Transfer Protein. Journal of Biological Chemistry. 1982;257(21):12901–07. PMID 7130186.
- ↑ Mattjus P. Glycolipid transfer proteins and membrane interaction. Biochimica et Biophysica Acta. 2009;1788:267–72. doi:10.1016/j.bbamem.2008.10.003. PMID 19007748.
- ↑ Brown RE, and Mattjus P. Glycolipid transfer proteins. Biochimica et Biophysica Acta. 2007;1771:746-60. doi:10.1016/j.bbalip.2007.01.011. PMID 17320476.
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