Flubendazole

Flubendazole
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	P02CA05 (WHO) QP52AC12 (WHO)
Identifiers
IUPAC name Methyl N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
CAS Number	31430-15-6^Y
PubChem (CID)	35802
DrugBank	DB08974^N
ChemSpider	32932^N
UNII	R8M46911LR^N
KEGG	D04200^Y
ChEBI	CHEBI:77095^N
ChEMBL	CHEMBL145946^N
ECHA InfoCard	100.046.007
Chemical and physical data
Formula	C₁₆H₁₂FN₃O₃
Molar mass	313.28 g/mol
3D model (Jmol)	Interactive image
Melting point	260 °C (500 °F)
SMILES COC(=O)Nc1[nH]c2ccc(cc2n1)C(=O)c3ccc(cc3)F
InChI InChI=1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)^N Key:CPEUVMUXAHMANV-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Flubendazole is an anthelmintic. Its brand name is Flutelmium which is a paste manufactured by Janssen Pharmaceutica N.V. used by veterinarians for protection against internal parasites and worms in dogs and cats. Other brand names are Flubenol, Biovermin, and Flumoxal.^[1]

It is also available for human use to treat worm infections. It is available OTC (without prescription) in Europe. Flubendazole-treated grit is used on UK grouse-shooting moors to reduce impact on the bird numbers from strongyle worm. Evidence of high worm burden is required before a veterinarian can dispense and sell the product, known as 'medicated grit'.^[2]

References

↑ US Patent 5824336 - Chewable flubendazole tablets for companion animals
↑ "Best practice use of medicated grit". Game and Wildlife Conservation Trust. Retrieved 27 September 2016.

Antiparasitics – Anthelmintics (P02) and Endectocides (QP54)

Antiplatyhelmintic agents

Antitrematodals
(schistosomicides)

Binds tubulin	benzimidazole Triclabendazole^#

AI	phosphonic acid Metrifonate^‡

Other/unknown	quinoline Praziquantel^# Oxamniquine^# phenol Bithionol thiazole Niridazole arylsulfonate Stibophen

Anticestodals
(taeniacides)

Binds tubulin	benzimidazole Albendazole^#

Other/unknown	quinoline Praziquantel^# salicylanilide Niclosamide^# aminoacridine Quinacrine butyrophenone Desaspidin chlorophenol Dichlorophen

Antinematodal agents
(including
macrofilaricides)

Binds tubulin	benzimidazole Mebendazole^# Albendazole^# Tiabendazole Fenbendazole Ciclobendazole Flubendazole

Glutamate-gated chloride channel, GABA receptor	avermectins Abamectin Doramectin Emamectin Ivermectin^# Selamectin milbemycins Moxidectin Milbemycin oxime

NMDA	tetrahydropyrimidine Pyrantel^# pyrantel pamoate Oxantel Morantel Carbantel Febantel (aka felsantel)

Other/unknown	piperazine Piperazine Diethylcarbamazine^# thiazole Levamisole^# quinolinium Pyrvinium benzylammonium Bephenium naphthalenesulfonate Suramin^# Tribendimidine

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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Flubendazole

See also

References