FXYD5

FXYD5
Identifiers
Aliases FXYD5, DYSAD, IWU1, KCT1, OIT2, PRO6241, RIC, HSPC113, FXYD domain containing ion transport regulator 5
External IDs MGI: 1201785 HomoloGene: 7458 GeneCards: FXYD5
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

53827

18301

Ensembl

ENSG00000089327

ENSMUSG00000009687

UniProt

Q96DB9

P97808

RefSeq (mRNA)

NM_001164605
NM_014164
NM_144779
NM_001320912
NM_001320913

NM_001111073
NM_001287213
NM_001287217
NM_008761

RefSeq (protein)

NP_001158077.1
NP_054883.3
NP_659003.1
NP_001307842.1

NP_001104543.1
NP_001274142.1
NP_032787.1

Location (UCSC) Chr 19: 35.15 – 35.17 Mb Chr 7: 31.03 – 31.04 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

FXYD domain-containing ion transport regulator 5 is a protein that in humans is encoded by the FXYD5 gene.[3]

Function

This reference sequence was derived from AF161462.1 and ESTs; validated by multiple replicate ESTs and human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, has not been characterized as a protein. Two transcript variants have been found for this gene, and they are both predicted to encode the same protein.[3]

References

Further reading


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