FGI-103

FGI-103
Legal status

Legal status	Investigational New Drug
Identifiers
IUPAC name 2-[(E)-2-(5-carbamimidoyl-1-benzofuran-2-yl)ethenyl]-3H-benzimidazole-5-carboximidamide
CAS Number	907169-69-1^Y
PubChem (CID)	5477931
ChemSpider	4585571
Chemical and physical data
Formula	C₁₉H₁₆N₆O
Molar mass	344.369
3D model (Jmol)	Interactive image
SMILES n4c2cc(C(N)=N)ccc2nc4\C=C\c3cc1cc(C(=N)N)ccc1o3
InChI InChI=1S/C19H16N6O/c20-18(21)10-2-5-16-12(7-10)8-13(26-16)3-6-17-24-14-4-1-11(19(22)23)9-15(14)25-17/h1-9H,(H3,20,21)(H3,22,23)(H,24,25)/b6-3+ Key:OOKWWPFCCCMWIS-ZZXKWVIFSA-N

FGI-103 is an antiviral drug developed as a potential treatment for the filoviruses Ebola virus and Marburg virus. In tests on mice FGI-103 was effective against both Ebola and Marburg viruses when administered up to 48 hours after infection. The mechanism of action of FGI-103 has however not yet been established, as it was found not to be acting by any of the known mechanisms used by similar antiviral drugs.^[1]^[2]^[3]

References

↑ Warren, T. K.; Warfield, K. L.; Wells, J.; Enterlein, S.; Smith, M.; Ruthel, G.; Yunus, A. S.; Kinch, M. S.; Goldblatt, M.; Aman, M. J.; Bavari, S. (2010). "Antiviral Activity of a Small-Molecule Inhibitor of Filovirus Infection". Antimicrobial Agents and Chemotherapy. 54 (5): 2152–9. doi:10.1128/AAC.01315-09. PMC 2863630. PMID 20211898.
↑ Bradfute, S. B.; Warfield, K. L.; Bray, M. (2012). "Mouse Models for Filovirus Infections". Viruses. 4 (12): 1477–1508. doi:10.3390/v4091477.
↑ De Clercq E. Ebola virus (EBOV) infection: Therapeutic strategies. Biochemical Pharmacology 1 January 2015, 93(1):1–10. doi:10.1016/j.bcp.2014.11.008

Family Filoviridae (Ebola virus disease, Marburg virus disease)

Ebolavirus

Species	Bundibugyo ebolavirus (BDBV) Reston ebolavirus (RESTV) Sudan ebolavirus (SUDV) Taï Forest ebolavirus (TAFV) Zaire ebolavirus (EBOV)

Outbreaks	List of Ebola outbreaks 1976 Sudan outbreak 1976 Zaire outbreak 2013−2016 West African Ebola virus epidemic Timeline Responses United Nations Ebola Response Fund Operation United Assistance in Guinea in Liberia in Mali in Sierra Leone in Spain in the United States in the United Kingdom Ouse to Ouse Tock Womey Massacre 2014 DR Congo outbreak

Drug candidates	BCX4430 Brincidofovir DZNep Favipiravir FGI-103 FGI-104 FGI-106 JK-05 Lamivudine Triazavirin ZMapp Vaccines cAd3-ZEBOV VSV-EBOV

Failed drug candidates	TKM-Ebola

Notable people	William Close Peter Piot Notable patients Ameyo Adadevoh Kent Brantly Pauline Cafferkey Thomas Eric Duncan Sheik Umar Khan Matthew Lukwiya Patrick Sawyer

In popular culture	The Hot Zone (1995 book) Outbreak (1995 film) Ebola Syndrome (1996 film) Executive Orders (1996 novel) 93 Days (2016 film)

Miscellaneous	Ebola virus disease Ebola River

Marburgvirus

Species	Marburg marburgvirus MARV RAVV

Drug candidates	BCX4430 FGI-103 FGI-106

In popular culture	The Hot Zone (1995 book)

Miscellaneous	Marburg virus disease Marburg

"Cuevavirus"
(proposed inclusion)

Species	"Lloviu cuevavirus" (LLOV)

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FGI-103

See also

References