FCRL3

FCRL3
Identifiers
Aliases FCRL3, CD307c, FCRH3, IFGP3, IRTA3, SPAP2, Fc receptor like 3
External IDs HomoloGene: 76447 GeneCards: FCRL3
Genetically Related Diseases
toxic diffuse goiter, multiple sclerosis, type 1 diabetes mellitus[1]
Orthologs
Species Human Mouse
Entrez

115352

n/a

Ensembl

ENSG00000160856

n/a

UniProt

Q96P31

n/a

RefSeq (mRNA)

NM_001024667
NM_052939
NM_001320333

n/a

RefSeq (protein)

NP_443171.2
NP_001307262.1

n/a

Location (UCSC) Chr 1: 157.67 – 157.7 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.[3][4][5]

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.[5]

Interactions

FCRL3 has been shown to interact with PTPN6.[6]

References

  1. "Diseases that are genetically associated with FCRL3 view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. doi:10.1073/pnas.171308498. PMC 55528Freely accessible. PMID 11493702.
  4. Davis RS, Dennis G Jr, Kubagawa H, Cooper MD (May 2002). "Fc receptor homologs (FcRH1-5) extend the Fc receptor family". Curr Top Microbiol Immunol. 266: 85–112. doi:10.1007/978-3-662-04700-2_7. PMID 12014205.
  5. 1 2 "Entrez Gene: FCRL3 Fc receptor-like 3".
  6. Xu, Ming-jiang; Zhao Runxiang; Cao Hongxi; Zhao Zhizhuang Joe (May 2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. United States. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. ISSN 0006-291X. PMID 12051764.

Further reading


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