Esuprone

Esuprone
Names

IUPAC name 3,4-Dimethyl-2-oxo-2H-chromen-7-yl ethanesulfonate
Identifiers
CAS Number	91406-11-0^N
3D model (Jmol)	Interactive image
ChEMBL	ChEMBL18504^Y
ChemSpider	59239^Y
PubChem	65827
UNII	K7EB9E48ZE^Y
InChI InChI=1S/C13H14O5S/c1-4-19(15,16)18-10-5-6-11-8(2)9(3)13(14)17-12(11)7-10/h5-7H,4H2,1-3H3^Y Key: CHDGAVDQRSPBTA-UHFFFAOYSA-N^Y InChI=1/C13H14O5S/c1-4-19(15,16)18-10-5-6-11-8(2)9(3)13(14)17-12(11)7-10/h5-7H,4H2,1-3H3 Key: CHDGAVDQRSPBTA-UHFFFAOYAR
SMILES O=S(=O)(Oc2ccc\1c(OC(=O)/C(=C/1C)C)c2)CC
Properties^[1]
Chemical formula	C₁₃H₁₄O₅S
Molar mass	282.31 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

Esuprone is an experimental drug candidate being investigated as an antidepressant.^[2] It acts as an monoamine oxidase A (MAO-A) inhibitor.^[3]

References

↑ Ganellin, C. R (1996). Dictionary of pharmacological agents. CRC Press. p. 1056. ISBN 978-0-412-46630-4.
↑ Vértes, Attila (2003). Handbook of nuclear chemistry. Springer. p. 155. ISBN 978-1-4020-1316-4.
↑ Bergström, M; Westerberg, G; Németh, G; Traut, M; Gross, G; Greger, G; Müller-Peltzer, H; Safer, A; et al. (1997). "MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: In vivo studies with positron emission tomography". European journal of clinical pharmacology. 52 (2): 121–8. doi:10.1007/s002280050260. PMID 9174681.

Common
(non-specific)

Inhibitors: Non-selective: Benmoxin Caroxazone Echinopsidine Furazolidone Guineesine Hydralazine Indantadol Iproclozide Iproniazid Isocarboxazid Isoniazid Linezolid Mebanazine Metfendrazine Nialamide Octamoxin Paraxazone Phenelzine Pheniprazine Phenoxypropazine Pivhydrazine Procarbazine Safrazine Tranylcypromine

Inhibitors: MAO-A-selective: Amiflamine Bazinaprine Befloxatone Brofaromine Cimoxatone Clorgiline CX157 (Tyrima) Eprobemide Esuprone Harmala alkaloids (e.g., harmine, harmaline, harman, norharman, tetrahydroharmine) Methylene blue Metralindole Minaprine Moclobemide Pirlindole Sercloremine Tetrindole Toloxatone

Inhibitors: MAO-B selective: Almoxatone D-Deprenyl Ethanol Ladostigil Lazabemide Milacemide Mofegiline Nicotine Pargyline^‡ Rasagiline Safinamide Selegiline (L-Deprenyl)

PAH	Inhibitors: 3,4-Dihydroxystyrene

TH	Inhibitors: 2-Hydroxyestradiol 2-Hydroxyestrone 3-Iodotyrosine Aquayamycin Bulbocapnine Metirosine Oudenone

DBH	Inhibitors: Bupicomide Disulfiram Dopastin Fusaric acid Nepicastat Phenopicolinic acid Tropolone

PNMT	Inhibitors: CGS-19281A SKF-64139 SKF-7698

COMT	Inhibitors: 2-Hydroxyestradiol 2-Hydroxyestrone Entacapone Nitecapone Tolcapone

TPH	Inhibitors: AGN-2979 Fenclonine (PCPA) Telotristat

See also: Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake and release modulators • Monoamine neurotoxins

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