Epalrestat

Epalrestat
Names
IUPAC name
2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid
Identifiers
82159-09-9 YesY
3D model (Jmol) Interactive image
ChEBI CHEBI:31539 N
ChEMBL ChEMBL56337 N
ChemSpider 1266086 N
ECHA InfoCard 100.200.343
KEGG D01688 YesY
PubChem 1549120
UNII 424DV0807X N
Properties
C15H13NO3S2
Molar mass 319.401 g/mol
Density 1.43 g/cm3
Melting point 210 °C (410 °F; 483 K)
Boiling point 516.8 °C (962.2 °F; 789.9 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Epalrestat is a carboxylic acid derivative[1] and a noncompetitive and reversible aldose reductase inhibitor used for the treatment of diabetic neuropathy, which is one of the most common long-term complications in patients with diabetes mellitus. It reduces the accumulation of intracellular sorbitol which is believed to be the cause of diabetic neuropathy, retinopathy and nephropathy [2][3] It is well tolerated, with the most commonly reported adverse effects being gastrointestinal issues such as nausea and vomiting, as well as increases in certain liver enzymes.[4] Chemically, epalrestat is unusual in that it is a drug that contains a rhodanine group. Aldose reductase is the key enzyme in the polyol pathway whose enhanced activity is the basis of diabetic neuropathy. Aldose reductase inhibitors (ARI) target this enzyme. Out of the many ARIs developed, ranirestat and fidarestat are in the trial stage. Others have been discarded due to unacceptable adverse effects or weak efficacy. Epalrestat is the only ARI commercially available.[5] It is easily absorbed into the neural tissue[6] and inhibits the enzyme with minimum side effects.[7]

Evidence

It has been proven in animal experiments that there is an improvement in sorbitol levels and Na+/K+ ATPase activity leading to improved nerve conduction velocity. Diabetic rats treated with epalrestat showed improvement in morphological abnormalities of nerves.[8] In a placebo controlled double blind trial of 196 patients, it was proved that Epalrestat in a dose of 150 mg/day improved the effects of diabetic neuropathy like upper limb spontaneous pain, motor nerve conduction velocity, thresholds of vibratory sensation and autonomic nerve function as compared to a placebo. These effects were significantly better in those with poorer control of diabetes.[9] A systematic review and metaanalysis showed that based on the results of 10 articles, it can be concluded that Epalrestat has some benefit in the control of diabetic cardiovascular autonomic neuropathy but only in the early or mild cases. It also doesn't influence glycaemic control.[10]

Brand names

References

  1. ↑ Terashima, H; Hama, K (1984). "Effects of a new aldose reductase inhibitor on various tissue in vitro". J Pharamacol Exp Ther. 229: 226–230.
  2. ↑ Ramirez, Mary Ann; Borja, Nancy L (May 2008). "Epalrestat: An Aldose Reductase Inhibitor for the Treatment of Diabetic Neuropathy". Pharmacotherapy. 28 (5): 646–655. doi:10.1592/phco.28.5.646.
  3. ↑ Steele, John W.; Faulds, Diana; Goa, Karen L. (1993). "Epalrestat". Drugs & Aging. 3 (6): 532–555. doi:10.2165/00002512-199303060-00007.
  4. ↑ Ramirez, Mary Ann; Borja, Nancy L (May 2008). "Epalrestat: An Aldose Reductase Inhibitor for the Treatment of Diabetic Neuropathy". Pharmacotherapy. 28 (5): 646–655. doi:10.1592/phco.28.5.646.
  5. ↑ Hotta, N; Akanuma, Y; Kawamori, R; Matsuoka, K; Oka, Y; Shichiri, M (July 2006). "Long-Term Clinical Effects of Epalrestat, an". Diabetes Care. 29 (7): 1538–44. doi:10.2337/dc05-2370. PMID 16801576. Retrieved 16 July 2016.
  6. ↑ Terashima, H; Hama, K; Yamamoto, R; Tsuboshima, M; Kikkawa, R; Hatanaka, I (1984). "Effects of a new aldose reductase inhibitor on various tissues in vitro.". J Pharmacol Exp Ther. 229: 226–30.
  7. ↑ Hotta, N; Sakamoto, N; Shigeta, Y; Kikkawa, G; Goto, Y; Diabetic Neuropathy Study (1996). "Clinical investigation of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy in Japan: multicenter study.". J Diabetes Complications. 10: 168–72. doi:10.1016/1056-8727(96)00113-4.
  8. ↑ Hotta, N; Sugimura, K; Kakuta, H; Fukasawa, H; Kimura, M; Koh, N (1988). Effects of a fructose rich diet and an aldose reductase inhibitor on the development of diabetic neuropathy in streptozotocin-treated rats. Amsterdam: Elsevier Science Publishers BV. p. 511.
  9. ↑ Goto, Y; Hotta, N; Shigeta, Y; Sakamoto, N; Kikkawa, R (1995). "Effects of an aldose reductase inhibitor, epalrestat, on diabetic neuropathy. Clinical benefit and indication for the drug assessed from the results of a placebo-controlled double-blind study.". Biomed Pharmacother. 49 (6): 269–77. doi:10.1016/0753-3322(96)82642-4. PMID 7579007.
  10. ↑ Xin, Hu; Li, Shengbing; Yang, Gangyi; Liu, Hua; Boden, Guenther; Li, Ling (2014). "Efficacy and Safety of Aldose Reductase Inhibitor for the Treatment of Diabetic Cardiovascular Autonomic Neuropathy: Systematic Review and Meta-Analysis". PLoS One. 9 (2): e87096. doi:10.1371/journal.pone.0087096. PMC 3922720Freely accessible.


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