Elisa Oricchio
| Elisa Oricchio | |
|---|---|
| Born |
1979 (age 36–37) Vallo della Lucania, Italy |
| Nationality | Italian |
| Alma mater |
Sapienza University of Rome University of Rome Tor Vergata |
| Occupation | Microbiologist |
| Years active | 2010–present |
| Employer | Memorial Sloan Kettering Cancer Center |
| Known for | Identifying the ephrin receptor A7 (EphA7) triggers tumor suppression in follicular lymphoma |
Elisa Oricchio (born 1979) is an Italian cancer researcher who discovered that EphA7 activates the tumor suppressor gene for patients with follicular lymphoma. She was awarded the Lorini Foundation Award and Blavatnik Award for Young Scientists for her discovery.
Biography
Elisa Oricchio was born in 1979[1] and grew up in Cilento, Italy.[2] She earned a bachelor's degree and went on to[3] attain a master's degree in biology from Sapienza University of Rome.[4] In 2008, she earned her PhD in Medical Microbiology and Immunology from the University of Rome Tor Vergata. Oricchio moved to the United States almost immediately to begin her post-doctorate research at Memorial Sloan Kettering Cancer Center in New York City. In her research, she identified in 2011 that tumor cells treated with pure EphA7, an anti-tumor protein, died, which was a significant discovery in a rarely researched field.[5] Her discovery was awarded with a grant from Sloan Kettering and a Fellowship from the Lymphoma Research Foundation[4] to make further studies of follicular lymphoma.[5] In addition to the research funds, she received the Lorini Foundation Award on 7 May 2012 in Milan, Italy[6] and the Blavatnik Award for Young Scientists in New York City, the same year.[4]
In 2012, her research identified that nearly 70% of patients with follicular lymphoma have lost the EphA7 receptor[5] and she was experimenting with methods of reintroducing the protein into the cells.[4] Because there has been no cure success with traditional chemotherapies,[7] Oricchio's work has repeatedly been funded. She was awarded a second Fellowship from the Leukemia and Lymphoma Society[4] and a grant from the US National Institutes of Health.[7] In 2013, she was awarded with a plaque from the town of Vallo della Lucania in her home region of Italy for her research,[2][8] which was successful in developing a mouse model.[9] In 2014, she was hired by the Swiss Federal Institute of Technology as a researcher and to support creation of the new Swiss Cancer Center in Lausanne at the Lausanne University Hospital.[1] The Swiss Institute for Experimental Cancer Research created an endowed Chair in Translational Oncology for Oricchio and effective 1 November 2014, she became a tenured Assistant Professor at the École Polytechnique Fédérale de Lausanne, School of Life Sciences.[9]
Selected publications
- Oricchio, Elisa; Saladino, Chiara; Iacovelli, Stefano; Soddu, Silvia; Cundari, Enrico (21 January 2006). "ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity". Cell Cycle. Rome, Italy: Institute of Biology and Molecular Pathology, National Research Council. 5 (1): 88–92. doi:10.4161/cc.5.1.2269.
- Bonaccorsi, Irene; Altieri, Fabio; Sciamanna, Ilaria; Oricchio, Elisa; Grillo, Caterina, et. al. (20 May 2008). "Endogenous reverse transcriptase as a mediator of ursolic acid's anti-proliferative and differentiating effects in human cancer cell lines". Cancer Letters. Messina, Italy: School of Pharmacy, University of Messina. 263 (1): 130–139. doi:10.1016/j.canlet.2007.12.026.
- Mavrakis, Konstantinos J; Wolfe, Andrew L; Oricchio, Elisa; Palomero, Teresa, et. al. (28 April 2010). "Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia". Nature Cell Biology. New York, New York: Nature Publishing Group. 12 (4): 372–379. doi:10.1038/ncb2037.
- Oricchio, Elisa; Wolfe, Andrew L; Schatz, Jonathan H; Mavrakis, Konstantinos J, et. al. (November–December 2010). "Mouse models of cancer as biological filters for complex genomic data". Disease Models & Mechanisms. Cambridge, UK: The Company of Biologists. 3 (11–12): 701–704. doi:10.1242/dmm.006296.
- Oricchio, Elisa; Nanjangud, Gouri; Wolfe, Andrew L; Schatz, Jonathan H, et. al. (October 2011). "The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma". Cell. Cambridge, Massachusetts: Elsevier Inc. 147 (3): 554–564. doi:10.1016/j.cell.2011.09.035.
- Oricchio, Elisa; Wendel, Hans-Guido (15 March 2012). "Mining the cancer genome uncovers therapeutic activity of EphA7 against lymphoma". Cell Cycle. New York, New York: Taylor & Francis. 11 (6): 1076–1080. doi:10.4161/cc.11.6.19451.
- Oricchio, Elisa; Wendel, Hans-Guido (July 2013). "Functional genomics lead to new therapies in follicular lymphoma". Annals of the New York Academy of Sciences. New York, New York: New York Academy of Sciences. 1293: 18–24. doi:10.1111/nyas.12120.
- Oricchio, Elisa; Ciriello, Giovanni; Jiang, Man; Boice, Michael H, et. al. (June 2014). "Frequent disruption of the RB pathway in indolent follicular lymphoma suggests a new combination therapy". Journal of Experimental Medicine. New York, New York: The Rockefeller University Press. 211 (7): 1379–1391. doi:10.1084/jem.20132120.
References
- 1 2 "24 new professors at the two Federal Institutes of Technology". Zürich, Switzerland: EthRat. 19 September 2014. Retrieved 22 November 2015.
- 1 2 "Negli Usa è al top della ricerca medica: premiata a Vallo la cilentana Elisa Oricchio" (in Italian). Napoli, Italy: Corriere del Mezzogiorno. 2 September 2013. Retrieved 21 November 2015.
- ↑ Santomauro, Antonella (28 April 2011). "Elisa Oricchio ha fatto il grande passo verso la grande mela con una laurea in biologia" (in Italian). Italy: Mollo Tutto. Retrieved 21 November 2015.
- 1 2 3 4 5 "Elisa Oricchio". New York, New York: Blavatnick Awards. 2012. Retrieved 21 November 2015.
- 1 2 3 "New Grantees" (PDF). Research Report. New York, New York: Lymphoma Research Foundation. 10 (1): 7. Winter 2012. Retrieved 21 November 2015.
- ↑ "Premiazione 2011" (in Italian). Milan, Italy: Fondazione Lorini. 7 May 2012. Retrieved 21 November 2015.
- 1 2 "Dissecting the Genetics Of Follicular Lymphoma To Find New Therapies". Grantome. 2014. Retrieved 21 November 2015.
- ↑ "Festeggiata Elisa Oricchio, di Vallo della Lucania, famosa ricercatrice sul linfoma follicolare" (in Italian). Cilento, Italy: Cilento Notizie. 29 August 2013. Retrieved 21 November 2015.
- 1 2 "A warm welcome to Elisa Oricchio!". Lausanne, Switzerland: École Polytechnique Fédérale de Lausanne. 31 October 2014. Retrieved 22 November 2015.