Convallatoxin
Names | |
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IUPAC name
(3S,5S,8R,9S,10S,13R,14S,17R)-5,14-dihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde | |
Other names
Strophanthin 3alpha-1-rhamnoside ; Strophanthidin alpha-l-rhamnopyranoside; Strophanthidin a-l-rhamnopyranoside; Corglykon;20(22),5beta-cardenolid-19-al-3beta,5beta,14beta-triol-3beta-d-[a-1-rhamnopyranoside] ; 5Beta,20[22]-cardenolide-19-one-3beta,5alpha,14-triol-3-[6-deoxy-alpha-l-mannopyranosyl] ; 3Beta,5alpha,14-trihydroxy-19-oxo-5beta,20[22]-cardenolide-3-[6-deoxy-alpha-l-mannopyranosyl] | |
Identifiers | |
508-75-8 | |
3D model (Jmol) | Interactive image |
ChEBI | CHEBI:27663 |
ChEMBL | ChEMBL399336 |
ChemSpider | 390428 |
ECHA InfoCard | 100.007.352 |
EC Number | 208-086-3 |
PubChem | 441852 |
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Properties | |
C29H42O10 | |
Molar mass | 550.65 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is ?) | |
Infobox references | |
Convallatoxin is a glycoside extracted from Convallaria majalis.
Action and uses
Similar to digitalis, it is mainly used for acute and chronic heart failure.
Detection
Convallatoxin can be detected alongside digoxin using luminescent oxygen channelling technology–based digoxin assay LOCI which could possibly detect other glycosides present in plasma derived from Lily of the Valley plant.
Based on the observed apparent digoxin concentration, convallatoxin concentration in the serum can be calculated using a formula: y = 89.9x2 – 524x + 617.3 y = convallotoxin (ng/mL) x = LOCI digoxin concentration (ng/mL)[1]
References
- ↑ Am J. Clin. Pathol. 2014 Sep;142(3):307-12. doi: 10.1309/AJCPCOXF0O5XXTKD. Rapid detection of the active cardiac glycoside convallatoxin of lily of the valley using LOCI digoxin assay. Welsh KJ, Huang RS, Actor JK, Dasgupta A.
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