Catuabine

Catuabines are a group of tropane alkaloids, isolated from Erythroxylum vacciniifolium, which are used in the preparation of the drug Catuaba (which in traditional Brazilian medicine is purported to be an aphrodisiac and central nervous system stimulant, though such has not been substantiated). While catuabine A, B and C were isolated and characterized by Graf and Lude (1977, 1978), catuabine D was recently isolated by Zanolari et al. The catuabines are not known to have any physiological effects, this is in contrast to cocaine, which is an active constituent of another species, Erythroxylum coca.

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  Catuabine A

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  Catuabine B

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  Catuabine C

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  Catuabine D

References

• Glasl, S.; Presser, A.; Werner, I.; Haslinger, E.; Jurenitsch, J. (2003): Tropane alkaloids from a Brazilian bark traded as "Catuaba". Scientia Pharmaceutica Vol. 71: 113-119. (ISSN 0036-8709, CODEN SCPHA4).
• Glasl, S.; Presser, A.; Werner, I.; Haslinger, E.; Jurenitsch, J. (2004): Erratum to Tropane alkaloids from a Brazilian bark traded as "Catuaba". Scientia Pharmaceutica Vol. 72: 97. (ISSN 0036-8709, CODEN SCPHA4).
• Graf, E.; Lude, W (1977): Alkaloids from Erythroxylum vacciniifolium Martius, 1. pt. Isolation of catuabine A, B and C. Archiv der Pharmazie (Weinheim) Vol. 310(12): 1005-1010. (ISSN 0365-6233, CODEN ARPMAS).
• Graf, E.; Lude, W. (1978): Alkaloids from Erythroxylum vacciniifolium Martius, 2. pt. The structures of catuabine A, B and C. Archiv der Pharmazie (Weinheim) Vol. 311(2): 139-152. (ISSN 0365-6233, CODEN ARPMAS).
• Zanolari, B.; Wolfeneder, J.L.; Guilet, D.; Marston, A.; Queiroz, E.F.; Paulo, M.Q.; Hostettmann, K. (2003): On-line identification of tropane alkaloids from Erythroxylum vacciniifolium by liquid chromatography-UV detection-multiple mass spectrometry and liquid chromatography-nuclear magnetic resonance spectrometry. Journal of Chromatogragraphy Vol. 1020A: 75-89. (ISSN 0021-9673, CODEN JCRAEY).
• Zanolari, B.; Guilet, D.; Marston, A.; Queiroz, E.F.; de Queiroz Paulo, M.; Hostettmann, K. (2003): Tropane alkaloids from the bark of Erythroxylum vacciniifolium. Journal of Natural Products Vol. 66(4): 497-502. (ISSN 0163-3864, CODEN JNPRDF).
• Zanolari, B.; Guilet, D.; Marston, A.; Queiroz, E.F.; de Queiroz Paulo, M.; Hostettmann, K. (2005): Methylpyrrole tropane alkaloids from the bark of Erythroxylum vacciniifolium. Journal of Natural Products Vol. 68(8): 1153-1158. (ISSN 0163-3864, CODEN JNPRDF).