Catalase-peroxidase

Catalase-peroxidase (EC 1.11.1.21, katG (gene)) is an enzyme with systematic name donor:hydrogen-peroxide oxidoreductase.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

(1) donor + H₂O₂

\rightleftharpoons

oxidized donor + 2 H₂O

(2) 2 H₂O₂

\rightleftharpoons

O₂ + 2 H₂O

This enzyme is a strong catalase with H₂O₂ as donor which releases O₂.

References

↑ Loewen, P.C.; Triggs, B.L.; George, C.S.; Hrabarchuk, B.E. (1985). "Genetic mapping of katG, a locus that affects synthesis of the bifunctional catalase-peroxidase hydroperoxidase I in Escherichia coli". J. Bacteriol. 162 (2): 661–667. PMC 218901. PMID 3886630.
↑ Hochman, A.; Goldberg, I. (1991). "Purification and characterization of a catalase-peroxidase and a typical catalase from the bacterium Klebsiella pneumoniae". Biochim. Biophys. Acta. 1077 (3): 299–307. doi:10.1016/0167-4838(91)90544-a. PMID 2029529.
↑ Fraaije, M.W.; Roubroeks, H.P.; van Berkel, W.H.J. (1996). "Purification and characterization of an intracellular catalase-peroxidase from Penicillium simplicissimum". Eur. J. Biochem. 235 (1-2): 192–198. doi:10.1111/j.1432-1033.1996.00192.x. PMID 8631329.
↑ Bertrand, T.; Eady, N.A.; Jones, J.N.; Jesmin, Nagy J.M.; Jamart-Gregoire, B.; Raven, E.L.; Brown, K.A. (2004). "Crystal structure of Mycobacterium tuberculosis catalase-peroxidase". J. Biol. Chem. 279 (37): 38991–38999. doi:10.1074/jbc.M402382200. PMID 15231843.
↑ Vlasits, J.; Jakopitsch, C.; Bernroitner, M.; Zamocky, M.; Furtmuller, P.G.; Obinger, C. (2010). "Mechanisms of catalase activity of heme peroxidases". Arch. Biochem. Biophys. 500 (1): 74–81. doi:10.1016/j.abb.2010.04.018. PMID 20434429.

Catalase-peroxidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: peroxidases (EC 1.11)

1.11.1.1-14	Catalase Cytochrome c peroxidase Eosinophil peroxidase Glutathione peroxidase GPX 1 2 3 4 5 6 7 8 Horseradish peroxidase Lactoperoxidase Myeloperoxidase Thyroid peroxidase Deiodinase Iodothyronine deiodinase Iodotyrosine deiodinase

1.11.1.15 (peroxiredoxin)	1 2 3 4 5 6

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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