Calcium/cholecalciferol

Calcium/cholecalciferol
Combination of
Calcium	Mineral nutrient
Cholecalciferol	Vitamin
Clinical data
AHFS/Drugs.com	Multum Consumer Information
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Oral
ATC code	A12AX (WHO)
Legal status
Legal status	US: OTC
Identifiers

Calcium/cholecalciferol is a combination of a calcium salt (usually calcium carbonate) and vitamin D₃ (cholecalciferol), available under many brand names and in many forms such as chewable tablets, coated tablets, and effervescent tablets. It is used to prevent and treat lack of calcium and vitamin D in the elderly, as well as adjunctive therapy for osteoporosis.^[1]^[2]

Adverse effects and overdose

Possible side effects include gastrointestinal problems, for example nausea and constipation. If very high doses are taken, signs of hypercalcaemia (too high blood calcium levels) have been described, such as stomach pain, vomiting, thirst, and tiredness. Extreme or long-term or overdose can theoretically result in hypervitaminosis D, kidney stones, renal insufficiency and calcinosis.^[1]^[2]

Interactions

Calcium forms complexes with a number of pharmaceutical drugs, reducing their bioavailability; among them are tetracyclines, quinolone antibiotics, levothyroxine, and bisphosphonates, as well as iron, magnesium and zinc supplements. Vitamin D in usual doses has no relevant interactions.^[2]

References

1 2 Multum Consumer Information on calcium and vitamin D combinations.
1 2 3 Haberfeld, H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag.

Mineral supplements (A12)

Major

Calcium	β-hydroxy-β-methylbutyrate carbonate chloride +cholecalciferol citrate glubionate glucoheptonate gluconate^# glycerylphosphate hydroxyapatite lactate gluconate lactate pangamate phosphate

Magnesium	aspartate chloride citrate gluconate glycinate lactate levulinate malate orotate oxide pidolate sulfate taurate

Phosphorus	adenosine triphosphate disodium hydroxyapatite monosodium phosphate

Potassium	bicarbonate bitartrate chloride citrate gluconate

Sodium	chloride sulfate

Sulfur	L-cysteine L-cystine L-glutathione L-methionine methylsulfonylmethane N-acetyl-L-cysteine R-α-lipoic acid S-adenosyl methionine taurine

Trace

Copper	gluconate

Iodine	potassium iodide

Iron	(II) fumarate (II) sulfate

Selenium	selenate selenite

Zinc	acetate L-aspartate L-carnosine gluconate oxide proteinate sulfate

Ultratrace

Chromium	(III) picolinate (III) chloride

Fluorine	fluoride^# monofluorophosphate

Lithium	aspartate carbonate orotate

Vanadium	(IV) sulfate

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

This article is issued from Wikipedia - version of the 6/17/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.