CREB5

CREB5
Identifiers
Aliases	CREB5, CRE-BPA, CREB-5, cAMP responsive element binding protein 5
External IDs	MGI: 2443973 HomoloGene: 18215 GeneCards: CREB5
Genetically Related Diseases
attention deficit hyperactivity disorder[1]
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • protein binding • metal ion binding • nucleic acid binding • transcription factor activity, sequence-specific DNA binding Cellular component • extracellular exosome • nucleus Biological process • positive regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9586	231991
Ensembl	ENSG00000146592	ENSMUSG00000053007
UniProt	Q02930	Q8K1L0
RefSeq (mRNA)	NM_001011666 NM_004904 NM_182898 NM_182899	NM_172728 NM_001327821
RefSeq (protein)	NP_001011666.1 NP_004895.2 NP_878901.2 NP_878902.2	NP_766316.1
Location (UCSC)	Chr 7: 28.3 – 28.83 Mb	Chr 6: 53.29 – 53.7 Mb
PubMed search	[2]	[3]
Wikidata

Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene.^[4][5][6]

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

References

Further reading