CACYBP

CACYBP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases CACYBP, GIG5, S100A6BP, SIP, PNAS-107, calcyclin binding protein
External IDs MGI: 1270839 HomoloGene: 7649 GeneCards: CACYBP
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

27101

12301

Ensembl

ENSG00000116161

ENSMUSG00000014226

UniProt

Q9HB71

Q9CXW3

RefSeq (mRNA)

NM_014412
NM_001007214

NM_009786

RefSeq (protein)

NP_001007215.1
NP_055227.1

NP_033916.1

Location (UCSC) Chr 1: 175 – 175.01 Mb Chr 1: 160.2 – 160.21 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene.[3][4][5]

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[5]

Interactions

CACYBP has been shown to interact with SKP1A[6] and SIAH1.[3]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. 1 2 Matsuzawa SI, Reed JC (Jun 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Mol Cell. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. PMID 11389839.
  4. Matsuzawa S, Li C, Ni CZ, Takayama S, Reed JC, Ely KR (Jan 2003). "Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP)". J Biol Chem. 278 (3): 1837–40. doi:10.1074/jbc.M210263200. PMID 12421809.
  5. 1 2 "Entrez Gene: CACYBP calcyclin binding protein".
  6. Matsuzawa, S I; Reed J C (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Mol. Cell. United States. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. ISSN 1097-2765. PMID 11389839.

Further reading


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