C8orf4
| C8orf4 | ||||||
|---|---|---|---|---|---|---|
| Identifiers | ||||||
| Aliases | C8orf4, TC-1, TC1, chromosome 8 open reading frame 4 | |||||
| External IDs | MGI: 1916318 HomoloGene: 10590 GeneCards: C8orf4 | |||||
| RNA expression pattern | ||||||
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| More reference expression data | ||||||
| Orthologs | ||||||
| Species | Human | Mouse | ||||
| Entrez | ||||||
| Ensembl | ||||||
| UniProt | ||||||
| RefSeq (mRNA) | ||||||
| RefSeq (protein) | ||||||
| Location (UCSC) | Chr 8: 40.15 – 40.16 Mb | Chr 8: 24.44 – 24.44 Mb | ||||
| PubMed search | [1] | [2] | ||||
| Wikidata | ||||||
| View/Edit Human | View/Edit Mouse |
Uncharacterized protein C8orf4 is a protein that in humans is encoded by the C8orf4 gene.[3][4]
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes.[4]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Chua EL, Young L, Wu WM, Turtle JR, Dong Q (Nov 2000). "Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer". Genomics. 69 (3): 342–7. doi:10.1006/geno.2000.6348. PMID 11056052.
- 1 2 "Entrez Gene: C8orf4 chromosome 8 open reading frame 4".
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241
. PMID 12477932. - Sunde M, McGrath KC, Young L, et al. (2004). "TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer.". Cancer Res. 64 (8): 2766–73. doi:10.1158/0008-5472.CAN-03-2093. PMID 15087392.
- Friedman JB, Brunschwig EB, Platzer P, et al. (2004). "C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer.". Int. J. Cancer. 111 (1): 72–5. doi:10.1002/ijc.20235. PMID 15185345.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Jung Y, Bang S, Choi K, et al. (2006). "TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby.". Cancer Res. 66 (2): 723–8. doi:10.1158/0008-5472.CAN-05-3124. PMID 16424001.
- Kim B, Koo H, Yang S, et al. (2007). "TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer.". Clin. Cancer Res. 12 (11 Pt 1): 3541–8. doi:10.1158/1078-0432.CCR-05-2440. PMID 16740781.
- Yang ZQ, Streicher KL, Ray ME, et al. (2007). "Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer.". Cancer Res. 66 (24): 11632–43. doi:10.1158/0008-5472.CAN-06-2946. PMID 17178857.
- Yang ZQ, Moffa AB, Haddad R, et al. (2007). "Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways.". Int. J. Cancer. 121 (6): 1265–73. doi:10.1002/ijc.22831. PMID 17520678.
- Park J, Jung Y, Kim J, et al. (2007). "TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response.". Biochem. Biophys. Res. Commun. 360 (2): 447–52. doi:10.1016/j.bbrc.2007.06.077. PMID 17603013.
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