Besonprodil

Besonprodil
Clinical data
ATC code None
Identifiers
Synonyms CI-1041
CAS Number 253450-09-8 N
PubChem (CID) 156328
ChemSpider 137662 YesY
UNII 5K3N2D15WW YesY
ChEMBL CHEMBL219631 YesY
Chemical and physical data
Formula C21H23FN2O3S
Molar mass 402.481 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Besonprodil (CI-1041) is a drug which acts as an NMDA antagonist, selective for the NR2B subunit.[1][2] It is under development as a supplemental medication for Parkinson's disease, and has been shown in animals to be effective in counteracting the dyskinesias associated with long term treatment with levodopa and related drugs.[3][4][5][6][7]

References

  1. ↑ Kovács G, Kocsis P, Tarnawa I, Horváth C, Szombathelyi Z, Farkas S (January 2004). "NR2B containing NMDA receptor dependent windup of single spinal neurons". Neuropharmacology. 46 (1): 23–30. doi:10.1016/S0028-3908(03)00339-3. PMID 14654094.
  2. ↑ Barton ME, White HS (March 2004). "The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on kindling acquisition and expression". Epilepsy Research. 59 (1): 1–12. doi:10.1016/j.eplepsyres.2003.12.010. PMID 15135162.
  3. ↑ Morissette M, Dridi M, Calon F, Hadj Tahar A, Meltzer LT, Bédard PJ, Di Paolo T (January 2006). "Prevention of levodopa-induced dyskinesias by a selective NR1A/2B N-methyl-D-aspartate receptor antagonist in parkinsonian monkeys: implication of preproenkephalin". Movement Disorders : Official Journal of the Movement Disorder Society. 21 (1): 9–17. doi:10.1002/mds.20654. PMID 16127720.
  4. ↑ Morissette M, Dridi M, Calon F, Hadj Tahar A, Meltzer LT, Bédard PJ, Di Paolo T (September 2006). "Prevention of dyskinesia by an NMDA receptor antagonist in MPTP monkeys: effect on adenosine A2A receptors". Synapse (New York, N.Y.). 60 (3): 239–50. doi:10.1002/syn.20295. PMID 16739115.
  5. ↑ Ouattara B, Belkhir S, Morissette M, Dridi M, Samadi P, Grégoire L, Meltzer LT, Di Paolo T (June 2009). "Implication of NMDA receptors in the antidyskinetic activity of cabergoline, CI-1041, and Ro 61-8048 in MPTP monkeys with levodopa-induced dyskinesias". Journal of Molecular Neuroscience : MN. 38 (2): 128–42. doi:10.1007/s12031-008-9137-8. PMID 18704766.
  6. ↑ Tamim MK, Samadi P, Morissette M, Grégoire L, Ouattara B, Lévesque D, Rouillard C, Di Paolo T (January 2010). "Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides". Neuropharmacology. 58 (1): 286–96. doi:10.1016/j.neuropharm.2009.06.030. PMID 19576910.
  7. ↑ Ouattara B, Hoyer D, Grégoire L, Morissette M, Gasparini F, Gomez-Mancilla B, Di Paolo T (June 2010). "Changes of AMPA receptors in MPTP monkeys with levodopa-induced dyskinesias". Neuroscience. 167 (4): 1160–7. doi:10.1016/j.neuroscience.2010.03.022. PMID 20303391.
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