Aphthovirus internal ribosome entry site (IRES)

Aphthovirus internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_Aptho
Identifiers
Symbol IRES_Aptho
Alt. Symbols Aptho_IRES
Rfam RF00210
Other data
RNA type Cis-reg; IRES
Domain(s) Viruses
GO 0043022
SO 0000243

This family represents the internal ribosome entry site (IRES) of the Picornaviruses.[1] IRES elements allow cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor eIF4F.[2]

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