Alexander Klibanov (biologist)
| Alexander Klibanov | |
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| Known for | Targeted contrast media for molecular ultrasonography |
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Alexander L. (Sasha) Klibanov (Russian: Александр Л. Клибанов) is Associate Professor in the Division of Cardiovascular Medicine and Department of Biomedical Engineering at the University of Virginia. He specializes in the study of ultrasound and medical imaging techniques.
Targeted microbubbles
Dr. Klibanov designed targeted microbubbles in 1997 [1] that launched a new medical imaging modality, named molecular ultrasonography or ultrasound molecular imaging.[2] Potential clinical applications are expected in cancer screening to detect malignant tumors at their earliest stage of appearance; with intravenous injection of targeted microbubbles that specifically bind to tumoral microvessels by targeting biomolecular cancer expression (overexpression of certain biomolecules occurs during neo-angiogenesis or inflammation processes).
References
- ↑ Klibanov, A. L.; Hughes, M. S.; Marsh, J. N.; Hall, C. S.; Miller, J. G.; Wilble, J. H.; Brandenburger, G. H. (1997). "Targeting of ultrasound contrast material. An in vitro feasibility study". Acta Radiologica Supplementum. 412: 113–120. PMID 9240089.
- ↑ Klibanov, A (1999). "Targeted delivery of gas-filled microspheres, contrast agents for ultrasound imaging". Advanced Drug Delivery Reviews. 37 (1–3): 139–157. doi:10.1016/S0169-409X(98)00104-5. PMID 10837732.