Acetoacetyl-CoA
Identifiers | |
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1420-36-6 | |
3D model (Jmol) | Interactive image |
ChEBI | CHEBI:15345 |
ChemSpider | 83198 |
ECHA InfoCard | 100.014.378 |
3039 | |
MeSH | acetoacetyl+CoA |
PubChem | 74 |
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Properties | |
C25H40N7O18P3S | |
Molar mass | 851.609 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is ?) | |
Infobox references | |
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway, which is essential for cholesterol biosynthesis. It also takes a similar role in the ketone bodies synthesis (ketogenesis) pathway of the liver. In the ketone bodies digestion pathway (in the tissue), it is no longer associated with having HMG-CoA as a product or as a reactant.
It is created from acetyl-CoA by thiolase, and it is acted upon by HMG-CoA synthase to form HMG-CoA. During the metabolism of leucine, this last reaction is reversed.
See also
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