AOC2

AOC2
Identifiers
Aliases AOC2, DAO2, RAO, amine oxidase, copper containing 2
External IDs MGI: 2668431 HomoloGene: 56457 GeneCards: AOC2
Orthologs
Species Human Mouse
Entrez

314

237940

Ensembl

ENSG00000131480

ENSMUSG00000078651

UniProt

O75106

Q812C9

RefSeq (mRNA)

NM_009590
NM_001158

NM_178932

RefSeq (protein)

NP_001149.2
NP_033720.2

NP_849263.1

Location (UCSC) Chr 17: 42.84 – 42.85 Mb Chr 11: 101.33 – 101.33 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Amine oxidase, copper containing 2 is a protein that in humans is encoded by the AOC2 gene.[3]

Function

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.

References

Further Reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia - version of the 5/19/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.