ALDH1A3

ALDH1A3
Identifiers
Aliases ALDH1A3, ALDH1A6, ALDH6, MCOP8, RALDH3, aldehyde dehydrogenase 1 family member A3
External IDs MGI: 1861722 HomoloGene: 68080 GeneCards: ALDH1A3
Orthologs
Species Human Mouse
Entrez

220

56847

Ensembl

ENSG00000184254

ENSMUSG00000015134

UniProt

P47895

Q9JHW9

RefSeq (mRNA)

NM_001293815
NM_000693
NM_001037224

NM_053080

RefSeq (protein)

NP_000684.2
NP_001280744.1

NP_444310.3

Location (UCSC) Chr 15: 100.88 – 100.92 Mb Chr 7: 66.39 – 66.43 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Aldehyde dehydrogenase 1 family, member A3, also known as ALDH1A3 or retinaldehyde dehydrogenase 3 (RALDH3), is an enzyme that in humans is encoded by the ALDH1A3 gene,[3]

Function

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or a cellular retinol-binding protein form.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Hsu LC, Chang WC, Hiraoka L, Hsieh CL (November 1994). "Molecular cloning, genomic organization, and chromosomal localization of an additional human aldehyde dehydrogenase gene, ALDH6". Genomics. 24 (2): 333–41. doi:10.1006/geno.1994.1624. PMID 7698756.
  4. "Entrez Gene: ALDH1A3".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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