AFF3

AFF3
Identifiers
Aliases AFF3, LAF4, MLLT2-like, AF4/FMR2 family member 3
External IDs MGI: 106927 HomoloGene: 1718 GeneCards: AFF3
Genetically Related Diseases
type 1 diabetes mellitus[1]
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

3899

16764

Ensembl

ENSG00000144218

ENSMUSG00000037138

UniProt

P51826

P51827

RefSeq (mRNA)

NM_001025108
NM_002285

NM_001290814
NM_010678

RefSeq (protein)

NP_001020279.1
NP_002276.2

n/a

Location (UCSC) Chr 2: 99.55 – 100.14 Mb Chr 1: 38.18 – 38.66 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

AF4/FMR2 family member 3 is a protein that in humans is encoded by the AFF3 gene.[4][5][6]

Function

This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.[6]

References

  1. ↑ "Diseases that are genetically associated with AFF3 view/edit references on wikidata".
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. ↑ Liao X, Ma C, Trask B, Massa H, Gilbert DJ, Staudt LM, Jenkins NA, Copeland NG (Jun 1996). "LAF4 maps to mouse chromosome 1 and human chromosome 2q11.2-q12". Mammalian Genome. 7 (6): 467–8. doi:10.1007/s003359900137. PMID 8662235.
  5. ↑ Ma C, Staudt LM (Jan 1996). "LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias". Blood. 87 (2): 734–45. PMID 8555498.
  6. 1 2 "Entrez Gene: AFF3 AF4/FMR2 family, member 3".

External links

Further reading

  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • von Bergh AR, Beverloo HB, Rombout P, van Wering ER, van Weel MH, Beverstock GC, Kluin PM, Slater RM, Schuuring E (Sep 2002). "LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia". Genes, Chromosomes & Cancer. 35 (1): 92–6. doi:10.1002/gcc.10091. PMID 12203795. 
  • Hiwatari M, Taki T, Taketani T, Taniwaki M, Sugita K, Okuya M, Eguchi M, Ida K, Hayashi Y (May 2003). "Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23)". Oncogene. 22 (18): 2851–5. doi:10.1038/sj.onc.1206389. PMID 12743608. 
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
  • To MD, Faseruk SA, Gokgoz N, Pinnaduwage D, Done SJ, Andrulis IL (Jul 2005). "LAF-4 is aberrantly expressed in human breast cancer". International Journal of Cancer. Journal International Du Cancer. 115 (4): 568–74. doi:10.1002/ijc.20881. PMID 15704140. 


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