4-chlorobenzoate dehalogenase

4-chlorobenzoate dehalogenase
Identifiers
EC number 3.8.1.6
CAS number 94047-11-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 4-chlorobenzoate dehalogenase (EC 3.8.1.6) is an enzyme that catalyzes the chemical reaction

4-chlorobenzoate + H2O 4-hydroxybenzoate + chloride

Thus, the two substrates of this enzyme are 4-chlorobenzoate and H2O, whereas its two products are 4-hydroxybenzoate and chloride.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 4-chlorobenzoate chlorohydrolase. This enzyme is also called halobenzoate dehalogenase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1BVQ, 1JXZ, and 1NZY.

References

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